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Title Page
1. What Is Metastasis?
2. Metastasis Requires Angiogenesis
3. What Is Tumor Angiogenesis
4. Normal Angiogenesis in Children
5. Normal Angiogenesis in Adults
6. Angiogenesis and Vascular Endothelial Cells
7. Angiogenesis and Regulatory Proteins
8. Angiogenesis and Cancer
9. Without Angiogenesis, Tumor Growth Stops
10. With Angiogenesis, Tumor Growth Proceeds
11. What Prompts Angiogenesis?
12. Activators of Angiogenesis
13. The Angiogenesis Signaling Cascade
14. Endothelial Cell Activation
15. Inhibitors of Angiogenesis
16. Angiogenesis Inhibitors and Primary Tumors
17. Angiogenesis Inhibitors and Metastasis
18. Angiogenesis and Tumor Dormancy
19. Cancer in Angiogenesis-Deficient Mice
20. Angiogenesis Inhibitors in the Treatment of Human Cancer
21. Drugs That Inhibit Angiogenesis Directly
22. Old Drug With a New Use
23. Drugs That Block the Angiogenesis Signaling Cascade
24. Drugs That Block Extracellular Matrix Breakdown
25. Drugs with Other Mechanisms of Action
26. On to Clinical Trials
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