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Immunological Disorders Overview

An immunological disease results from the disorder of the immune system. It may fall into one of these categories: allergic diseases, autoimmune diseases, immune complex diseases, and immunodeficiency disorders.

Allergic Diseases

The most common types of allergic diseases occur when the immune system responds to a false alarm. In an allergic person, a normally harmless material such as grass pollen or house dust is mistaken for a threat and attacked.

Allergies such as pollen allergy are related to the antibody known as IgE. Like other antibodies, each IgE antibody is specific; one acts against oak pollen, another against ragweed.

Autoimmune Diseases

Sometimes the immune system's recognition apparatus breaks down, and the body begins to manufacture T cells and antibodies directed against its own cells and organs. Misguided T cells and autoantibodies, as they are known, contribute to many diseases. For instance, T cells that attack pancreas cells contribute to diabetes, while an autoantibody known as rheumatoid factor is common in people with rheumatoid arthritis. People with systemic lupus erythematosus (SLE) have antibodies to many types of their own cells and cell components.

No one knows exactly what causes an autoimmune disease, but multiple factors are likely to be involved. These include elements in the environment, such as viruses, certain drugs, and sunlight, all of which may damage or alter normal body cells. Hormones are suspected of playing a role, since most autoimmune diseases are far more common in women than in men. Heredity, too, seems to be important. Many people with autoimmune diseases have characteristic types of self marker molecules.

Immune Complex Diseases

Immune complexes are clusters of interlocking antigens and antibodies. Normally, immune complexes are rapidly removed from the bloodstream. Sometimes, however, they continue to circulate, and eventually become trapped in the tissues of the kidneys, the lungs, skin, joints, or blood vessels. There they set off reactions with complement that lead to inflammation and tissue damage.

Immune complexes work their mischief in many diseases. These include malaria and viral hepatitis, as well as many autoimmune diseases.

Immunodeficiency Disorders

When the immune system is missing one or more of its components, the result is an immunodeficiency disorder. Immunodeficiency disorders can be inherited, acquired through infection, or produced unintentionally by drugs such as those used to treat people with cancer or those who have received transplants.

Temporary immune deficiencies can develop in the wake of common virus infections, including influenza, infectious mononucleosis, and measles. Immune responses can also be depressed by blood transfusions, surgery, malnutrition, smoking, and stress.

Some children are born with poorly functioning immune systems. Some have flaws in the B cell system and cannot produce antibodies. Others, whose thymus is either missing or small and abnormal, lack T cells. Very rarely, infants are born lacking all of the major immune defenses. This condition is known as severe combined immunodeficiency disease or SCID.

AIDS is an immunodeficiency disorder caused by a virus (HIV) that infects immune cells. HIV can destroy or disable vital T cells, paving the way for a variety of immunologic shortcomings. HIV also can hide out for long periods in immune cells. As the immune defenses falter, a person with AIDS falls prey to unusual, often life-threatening infections and rare cancers.

 

Reference:

National Institute of Allergy and Infectious Diseases, USA.