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Ménétrier's Disease

Ménétrier disease causes the ridges along the inside of the stomach wall—called rugae—to enlarge, forming giant folds in the lining of the stomach. The rugae enlarge because of an overgrowth of surface mucous cells of the stomach. In a normal stomach, rugae release protein-containing mucus. Enlarged rugae release too much mucus, causing a leakage of protein from the blood into the stomach. This shortage of protein in the blood is known as hypoproteinemia. Ménétrier disease also causes a decrease in stomach acid resulting from a reduction in acid-producing parietal cells.

People with Ménétrier disease suffer from severe stomach pain, nausea, frequent vomiting, and other symptoms. They also have a higher risk of developing stomach cancer, also called gastric cancer.

Ménétrier disease is also called hypoproteinemic hypertrophic gastropathy.

Other conditions that can cause enlarged rugae but are not Ménétrier disease include

  • Zollinger-Ellison syndrome—a condition in which tumors in the pancreas cause the stomach to make too much acid
  • syphilis—a type of sexually transmitted bacterial infection
  • cytomegalovirus—a type of viral infection
  • histoplasmosis—a type of fungal infection
  • linitis plastica—a type of gastric cancer
  • gastric lymphoma—a type of cancer originating in the stomach


What causes Ménétrier disease is unclear; however, it is thought to be an acquired disorder with no known genetic component. Recent studies suggest people with Ménétrier disease have stomachs that make abnormally high amounts of a protein called transforming growth factor-alpha (TGF-α). Growth factors are proteins in the body that tell cells what to do, such as grow larger, change shape, or divide to make more cells. A cause for the overproduction of TGF-α has yet to be found.


Possible signs and symptoms of Ménétrier disease include

  • severe pain in the top middle part of the abdomen
  • nausea and frequent vomiting
  • swelling of the face, abdomen, limbs, and feet
  • loss of appetite
  • extreme weight loss
  • malnutrition
  • low blood protein
  • anemia
  • diarrhea


Ménétrier disease is diagnosed through x rays, endoscopy, and biopsy of stomach tissue. Endoscopy involves looking at the inside of the stomach using a long, lighted tube inserted through the mouth. During a biopsy, the doctor removes a small piece of tissue and examines it with a microscope for signs of disease.


Treatment may include medications to relieve nausea and pain. A high-protein diet is prescribed to offset the loss of protein from enlarged rugae. Part or all of the stomach may need to be removed if the disease is severe.

The anticancer drug cetuximab (Erbitux) blocks the action of TGF-α and is being investigated as a promising new treatment for Ménétrier disease.



National Digestive Diseases Information Clearinghouse, USA.