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Bioinformatics

 


What is Bioinformatics? - From NCBI

Bioinformatics is the field of science in which biology, computer science, and information technology merge into a single discipline. The ultimate goal of the field is to enable the discovery of new biological insights as well as to create a global perspective from which unifying principles in biology can be discerned. There are three important sub-disciplines within bioinformatics:

  • the development of new algorithms and statistics with which to assess relationships among members of large data sets
  • the analysis and interpretation of various types of data including nucleotide and amino acid sequences, protein domains, and protein structures
  • the development and implementation of tools that enable efficient access and management of different types of information.

Online Lectures

S-Star.org - (video and slides, 10+ lectures, Great!!!)

Sequence Analysis:

Blast information - From NCBI

BioComputing Hypertext Coursebook - From University of Bielefeld

Structural Prediction:

CMBI homology modelling course

The PredictProtein server

The PSIPRED Protein Structure Prediction Server

THREADER - Predicting the fold of a protein.

SWISS-MODEL - An Automated Comparative Protein Modelling Server.

PROSITE - Database of protein families and domains.

Review Article:

Cross-Species Sequence Comparisons: A Review of Methods and Available Resources - Genome Research, 2003