MoBio Signaling by STAT Chapter 6

STAT stands for "Signal Transducer and Activator of Transcription", because this class of proteins function as both signal transducer and transcription activator. They are inactive as a monomer. Activation involves phosphorylation and dimerization (Illustration).

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Figure 6-F-3. The domain organization of the STAT protein. The DNA binding domain may be used to activate transcription and the SH2 domain may receive signal from tyrosine kinase such as Jak. Most cytokines use the Jak-STAT signaling pathway.