Non-receptor Tyrosine Kinases

Three major classes of non-receptor tyrosine kinases have been identified: Src, Abl and Jak.

Review Articles:

SRC family kinases in cell volume regulation - Am. J. Physiol., 2005.

Series Introduction: JAK-STAT signaling in human disease - J. Clinical Investigation, 2002

Lymphocyte signal transduction - J. Clin. Invest., 2002.

• Introduction
• Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases
• Membrane domains and the immunological synapse: keeping T cells resting and ready
• ITAMs versus ITIMs: striking a balance during cell regulation
• Activation and inhibition of lymphocytes by costimulation
• Adapters in lymphocyte signaling
• T helper subset development: roles of instruction, selection, and transcription
• Death receptors couple to both cell proliferation and apoptosis
  

The molecular biology of chronic myeloid leukemia (involving Abl and Bcr proteins) - Blood, 2000.

The Jak-Stat pathway in normal and perturbed hematopoiesis - Blood, 2000.

Src-Related Protein Tyrosine Kinases in Hematopoiesis - Blood, 1999.

Signaling Pathways Activated by Oncogenic Forms of Abl Tyrosine Kinase - J. Biol. Chem., 1999.