Signaling via G-protein-Coupled Receptors

Figure 6-D-1.  Signaling via G-protein-coupled receptors.  
(a) Before agonist binding to the G-protein-coupled receptor, the three subunits of a G protein are bound together.  
(b) The agonist binding causes interaction between the G-protein-coupled receptor and the G protein.  
(c) Their interaction results in the dissociation between a and bg subunits of the G protein.  The separated a and/or bg subunits may then interact with effectors.

Review Articles:

Multi-Tasking RGS Proteins in the Heart - Circulation Research, 2005.

G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology - Mol. Pharma., 2004.

G Protein–Coupled Receptor Oligomerization - Circulation Research, 2004.

The G_bg dimer as a novel source of selectivity in G-Protein Signaling - Mol. Interven., 2004.

Lysophospholipid G Protein-coupled Receptors - J. Biol. Chem., 2004.

What Is the Role of b-Adrenergic Signaling in Heart Failure? - Circulation Research, 2003.

Regulation of G Protein-Coupled Receptor Kinases and Arrestins - Mol. Pharma., 2003.

Molecular Mechanisms of Bitter and Sweet Taste Transduction - J. Biol. Chem., 2002.

Signaling by Heterotrimeric G Proteins Minireview Series - J. Biol. Chem., 1998.

• The Many Faces of G Protein Signaling
• G Protein-Coupled Receptors I. Diversity of Receptor-Ligand Interactions
• G Protein-Coupled Receptors II.  Mechanism of Agonist Activation
• G Protein-Coupled Receptors III.  New Roles for Receptor Kinase and b Arrestins in Receptor Signaling and Desensitization
• The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades