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Lipid synthesis occurs at the smooth endoplasmic reticulum. Two examples are shown in Figures 5-E-1 and 5-E-2. Lipids may be transported to appropriate locations by vesicles or by phospholipid exchange proteins.
Figure 5-E-1. Synthesis of phosphatidylethanolamine (a phospholipid).
(b)
Figure 5-E-2. Synthesis of cholesterol. (a) Four stages are involved. (b) More detail on the first stage. HMG-CoA reductase inhibitors have been widely used to treat hypercholesterolemia (high cholesterol level).
Site of Interest: Lipid Synthesis - From the online textbook Medical Biochemistry. Review Article: The Enzymes of Neutral Lipid Synthesis - J. Biol. Chem., 2001
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