MoBio Synthesis of Lipids Chapter 5

Lipid synthesis occurs at the smooth endoplasmic reticulum. Two examples are shown in Figures 5-E-1 and 5-E-2. Lipids may be transported to appropriate locations by vesicles or by phospholipid exchange proteins.

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Figure 5-E-1. Synthesis of phosphatidylethanolamine (a phospholipid).

The synthesis of cholesterol involves four stages:

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Detail of the first stage is shown in the following figure:

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Figure 5-E-2. The first stage of cholesterol synthesis. HMG-CoA reductase inhibitors have been widely used to treat hypercholesterolemia (high cholesterol level).