MoBio Frameshift Chapter 5

In most cases, frameshift involves the insertion or deletion of a single nucleotide in mRNA. Theoretically, it could involve more than one nucleotide, as long as the number is not a multiple of 3. When a nucleotide is added to or deleted from the mRNA, the subsequent sequence will produce an entirely different peptide.

Image

Figure 5-C-2. Illustration of the frameshift. mRNA(a) and mRNA(b) differ by only one nucleotide: mRNA(b) has an additional nucleotide "G" at the third position in this figure. Note that the translated amino acids are entirely different after the insertion point.