|MoBio||Generation of Retroviral Genomic RNA||Chapter 4|
Replication of RNA retroviruses requires generation of retroviral genomic RNA from the integrated DNA. This involves the regular DNA to RNA transcription. The retroviral DNA contains two long terminal repeats (LTR), but only the upstream LTR directs transcription. Another LTR directs the cleavage of the primary transcript to add a poly-A tail.