The action of transcription factors can either stimulate or inhibit gene expression. They must be regulated so that a gene is expressed only when its product is needed. The following are a few examples.
lac repressor
l repressor (cI)
NF-kB
p53
Review Articles:
Dynamic
Combinatorial Networks in Nuclear Receptor-mediated Transcription
- J. Biol. Chem., 2005.
FOXO
Transcription Factors as Regulators of Immune Homeostasis: Molecules to Die
for? - J. Immunology, 2003.
Glucose Regulation
of Gene Transcription - J. Biol. Chem., 2000.
Signaling
pathways in insulin action: molecular targets of insulin resistance - J. Clinical Investigation,
2000.
Sterol
Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional
Homeostasis and Insulin Action - J. Biol. Chem., 2000.
Fatty Acid
Regulation of Gene Transcription - J. Biol. Chem., 2000.
Roles
of the heat shock transcription factors in regulation of the heat shock response
and beyond - FASEB J., 2001.
Nitrosation
and oxidation in the regulation of gene expression - FASEB J., 2000.
Transcriptional
activation: risky business (Regulation of GCN4 by srb10) - Genes and
Development, 2001.
Class II
Transactivator: Mastering the Art of Major Histocompatibility Complex
Expression - Molecular and Cellular Biology, 2001.
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