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Figure 4-G-3. An example of transcriptional activation by histone acetylation. p300/CBP can interact with a variety of transcriptional regulators such as pCAF (a histone acetyltransferase) and TBP (which recognizes the promoter). During transcription, they are all assembled at the promoter region. Histone acetylation by p300/CBP. pCAF and TAFII250 facilitates the transcription.
Figure 4-G-4. An example of transcriptional repression by histone deacetylation. The repressor Mad/Max dimer interacts with SIN3 (or N-CoR, SMRT, etc.) which recruits histone deacetylase (HDs) to repress transcription.
Review Articles: Control of Cardiac Growth by Histone Acetylation/Deacetylation - Circulation Research, 2006. Histone deacetylases (HDACs): characterization of the classical HDAC family - Biochem. J., 2003. The Max Network Gone Mad - Molecular and Cellular Biology, 2001. Deconstructing Myc - Genes and Development, 2001. Co-repressors 2000 - FASEB J., 2000. Transcriptional repression: the long and the short of it - Genes and Development, 2001.
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