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CBP and p300 are highly related histone acetyltransferases (HATs). The following figure shows the domain structure of p300.
Figure 4-G-2. The domain structure of p300 and the regions interacting with transcription regulators. "Bromo" represents Bromodomain which specifically binds to acetylated lysine. "CH-1, CH-2 and CH-3" are cysteine/histidine-rich regions.
Review Articles: CREB-binding Protein and p300 in Transcriptional Regulation - J. Biol. Chem., 2001. CREB-binding protein and p300: molecular integrators of hematopoietic transcription - Blood, 2000. CBP/p300 in cell growth, transformation, and development - Genes and Development, 2000.
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