MoBio Helix-Loop-Helix Chapter 4

"Helix-Loop-Helix" is characterized by two α helices connected by a loop. It should not be confused with "Helix-Turn-Helix". In fact, these two structures are quite different, but the Helix-Loop-Helix looks like leucine zipper. Example: myoblast determination proteins (MyoD).

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Figure 4-F-6. The transcription factor MyoD. (A) The domain organization. (B) The structure of the helix-loop-helix motif. PDB ID = 1MDY.