|MoBio||Leucine Zipper||Chapter 4|
Like many other transcription factors, the leucine-zipper-containing transcription factors bind DNA as dimers. A leucine zipper is formed by two α helices, one from each monomer. The helices are held together by hydrophobic interactions between leucine residues, which are located on one side of each helix. Examples include AP-1, CREB, and Gcn4.