MoBio Leucine Zipper Chapter 4

Like many other transcription factors, the leucine-zipper-containing transcription factors bind DNA as dimers. A leucine zipper is formed by two α helices, one from each monomer. The helices are held together by hydrophobic interactions between leucine residues, which are located on one side of each helix. Examples include AP-1, CREB, and Gcn4.

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Figure 4-F-5. (A) The domain organization of the transcription factor Jun. (B) The structure of the AP-1/DNA complex. AP-1 is a dimer formed by Jun and its homologous protein Fos. It contains a leucine zipper motif where two α helices look like a zipper with leucine residues (green color) lining on the inside of the zipper. PDB ID = 1FOS.