Figure 4-E-2. Assembly of the pre-initiation complex
(PIC). TBP first binds to the promoter and then recruits TFIIB to join TFIID (and TFIIA if present).
Before entering PIC, RNA Pol II and TFIIF are bound together, which are recruited by
TFIIB. Finally, RNA Pol II recruits TFIIE, which further recruits TFIIH to complete the
Table 4-E-1. General transcription factors
associated with RNA Pol II in human cells.