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Figure 4-E-2. Assembly of the pre-initiation complex (PIC). TBP first binds to the promoter and then recruits TFIIB to join TFIID (and TFIIA if present). Before entering PIC, RNA Pol II and TFIIF are bound together, which are recruited by TFIIB. Finally, RNA Pol II recruits TFIIE, which further recruits TFIIH to complete the PIC assembly.
Table 4-E-1. General transcription factors associated with RNA Pol II in human cells.
Review Articles: Phosphorylation and functions of the RNA polymerase II CTD - Genes and Development, 2006. Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression - Genes and Development, 2003. RNA polymerase II and the integration of nuclear events - Genes and Development, 2000.
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