|MoBio||Response Elements||Chapter 4|
Response elements are the recognition sites of certain transcription factors (Table 4-C-4). Most of them are located within 1 kb from the transcriptional start site.
*(A/T)6 means six A or T; N = any.
The cAMP response element (CRE) interacts with CREB (CRE-binding protein), which is regulated by cAMP (see Figure 6-F-1).
Estrogen response element (ERE) and glucocorticoid response element (GRE) are the recognition sites of estrogen receptor and glucocorticoid receptor, respectively. Note that hormones are not transcription factors, but many of their receptors are. Figure 4-C-5 shows the domain structures of a few steroid receptors.
Heat shock response element (HSE) is present in heat shock protein genes. In response to external stress (e.g. high temperature), the heat shock factor (HSF) will interact with HSE, stimulating expression of heat shock proteins.
Serum response element (SRE) binds to serum response factor (SRF), which can be activated by many growth factors in serum. The Fos subunit of AP-1 is encoded by a gene containing SRE. Fos is known to play an important role in cell cycle progression.