Home   >   Molecular Biology   >   Nucleic Acids

Conformations of Chromatin Fibers

 


The structure of chromatin fibers is dynamically changing.  In the condensed state, each nucleosome is associated with an H1 (or H5) to form a solenoid structure.  H1 and H5 are called linker histones.  They are essential in stabilizing the solenoid conformation.  This can be demonstrated by extracting the condensed chromatin at a low salt concentration, which will release H1 or H5.  Then, the "beads-on-a-string" conformation may be observed by the atomic force microscopy (web link).

Figure 3-D-4.  Chromatin's beads-on-a-string conformation and the solenoid structure.