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Small RNA Molecules |
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Major types of small RNA molecules:
Both miRNA and siRNA are about 20-25 nucleotides long. They are functionally equivalent, but differ in biogenesis. miRNAs are produced from transcripts that form stem-loop structures. In contrast, siRNAs are produced from long double-stranded RNA precursors (reference). These RNAs have been widely used in functional genomics and also have therapeutic potential.
Review Articles: Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes - Genes and Develop., 2006. Control of translation and mRNA degradation by miRNAs and siRNAs - Genes and Develop., 2006. RNA meets chromatin - Genes and Develop., 2005. MicroRNA function: Multiple mechanisms for a tiny RNA? - RNA, 2005 MicroRNA Biogenesis and Cancer - Cancer Research, 2005. Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? - Biochem. J., 2005. RNA interference: from model organisms towards therapy for neural and neuromuscular disorders - Hum. Mole. Genet., 2004. Optimizing RNA interference for application in mammalian cells - Biochem. J., 2004. RNA interference - BMJ 2004. RNA Interference in Biology and Medicine - Pharmaco. Rev., 2003. RNA Interference: Biology, Mechanism, and Applications - Microbiology and Molecular Biology Reviews, 2003. The dsRNA binding protein family: critical roles, diverse cellular functions - FASEB J., 2003. RNA-guided Nucleotide Modification of Ribosomal and Other RNAs - J. Biol. Chem., 2003. Micro-RNAs : small is plentiful - J. Cell Biol., 2002. Why do miRNAs live in the miRNP? - Genes and Development, 2002. Small Nuclear RNA Genes: a Model System to Study Fundamental Mechanisms of Transcription - J. Biol. Chem., 2001. RNA interference: 2001 - Genes and Development, 2001.
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