Chemokines are the cytokines that may activate or chemoattract
leukocytes. Each chemokine contains 65 ~ 120 amino acids, with molecular
weight of 8 ~ 10 kD. Their receptors belong to G-protein-coupled
receptors. Since the entry of HIV into
host cells requires chemokine receptors, their antagonists are being
developed to treat AIDS.
Site of Interest:
Short Lectures on Chemokines
- by University of Stony Brook.
Review Articles:
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment - Blood, 2006.
HIV and the chemokine system: 10 years later - EMBO J., 2006.
Chemokines
in the Pathogenesis of Vascular Disease - Circulation Research, 2004.
Chemokines
in joint disease: the key to inflammation? - Ann. Rheumatic Diseases, 2004.
Chemokine
receptors and their role in inflammation and infectious diseases - Blood,
2000.
Inhibition
of HIV Infection by Bicyclams, Highly Potent and Specific CXCR4 Antagonists
- Molecular Pharmacology, 2000.
Chemokine
Regulation of Normal and Pathologic Immune Responses - Stem Cells, 2001.
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