Membrane Attached Proteins

Membrane-attached proteins can be divided into three groups:

• bound to the cytosolic face of the plasma membrane by myristate;
• bound to the cytosolic face of the plasma membrane by farnesyl;
• bound to the extracelluar face of the plasma membrane by glycosylphosphatidylinositol.

Figure 2-F-6.  Illustration of anchors by which some proteins are bound to the plasma membrane.  v-Src is a kind of non-receptor protein tyrosine kinase involved in cell signaling.  Ras protein also plays a key role in cell signaling (Chapter 6 Section E).

Review Article:

The Biology and Enzymology of Protein N-Myristoylation - J. Biol. Chem., 2001.