Transport Proteins

According to the Transport Commission (TC) system, all transport proteins may be divided into the following classes:

Channels/Pores

Examples: ion channels, porins

Electrochemical Potential-driven transporters

Examples: uniporters,  symporters and antiporters

Primary Active Transporters

Examples: Na⁺-K⁺ ATPase,  H⁺ ATPase, ABC Transporter Superfamily and CFTR channel.

Group Translocators

Transport Electron Carriers

Auxiliary Transport Proteins

Incompletely Characterized

Review Articles:

Adenylate Kinase Activity in ABC Transporters - J. Biol. Chem., 2005.

Structures and Models of Transporter Proteins - Pharm. Experi. Thera., 2004.

The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA? - Mol. Pharm., 2004.

Amino acid transporters: roles in amino acid sensing and signalling in animal cells - Biochem. J., 2003.

From European J. Biochem., 2002

• Sodium pump and steroid hormone receptor: Na⁺/K⁺-ATPase
• The sodium pump: Its molecular properties and mechanics of ion transport
• Na⁺/K⁺-ATPase as a signal transducer
• Endogenous cardiac glycosides, a new class of steroid hormones 

Role of Alternative Splicing in Generating Isoform Diversity Among Plasma Membrane Calcium Pumps - Physiological Reviews, 2001.

Transport ATPase Trafficking - J. Biol. Chem., 2001.

• Introduction
• The Yeast Pma1 Proton Pump: a Model for Understanding the Biogenesis of Plasma Membrane Proteins - 
• Ion Pumps in Polarized Cells: Sorting and Regulation of the Na⁺,K⁺- and H⁺,K⁺-ATPases - J. Biol. Chem., 2001.

The vesicular neurotransmitter transporters: current perspectives and future prospects - FASEB J., 2000.

The role of the TolC family in protein transport and multidrug efflux - Eur. J. Biochem., 2001.

The drug/metabolite transporter superfamily - Eur. J. Biochem., 2001.

The Human ATP-Binding Cassette (ABC) Transporter Superfamily - Genome Research, 2001.