Ion Channels

Basic information about ion channels

Classification and Nomenclature of Ion Channels - Pharmacological Review, 2003.

Review Articles

General

• The Voltage Sensor in Voltage-Dependent Ion Channels - Physiol. Review, 2000.
• Ion channel genes and human neurological disease: Recent progress, prospects, and challenges - PNAS, 1999.

Potassium Channels

• Structure and Function of Kv4-Family Transient Potassium Channels - Physiol. Review, 2004.
• Evidence for Mitochondrial K⁺ Channels and Their Role in Cardioprotection - Circulation Research, 2004.
• A-type potassium currents in smooth muscle - Am. J. Physiol., 2002.
• Potassium Channel Function in Vascular Disease - Arteriosclerosis, Thrombosis, and Vascular Biology, 2001.
• Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities - Pharmacological Reviews, 2000.

Sodium Channels

• Inherited disorders of voltage-gated sodium channels - J. Clin. Invest., 2005.
• Regulation of the epithelial sodium channel by accessory proteins - Biochem., 2003.
• Epithelial Sodium Channel - Physiol. Review, 2002.

Calcium Channels

• The L-type calcium channel in the heart - J. Clin. Invest., 2005.
• Ca²⁺ Channels As Integrators of G Protein-Mediated Signaling in Neurons - Mol. Pharm., 2004.
• Dissecting the functional role of different isoforms of the L-type Ca²⁺ channel - J. Clin. Invest., 2004.
• g Subunit of Voltage-activated Calcium Channels - J. Biol. Chem., 2003.
• Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels - Physiol. Review, 2002.

Chloride channels

• Molecular Structure and Physiological Function of Chloride Channels - Physiol. Review, 2002.
• Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Cl Channel by Its R Domain - J. Biol. Chem., 2001.
• Cystic Fibrosis Transmembrane Conductance Regulator: Structure and Function of an Epithelial Chloride Channel - J. Biol. Chem., 2000.

Synaptic Channels

• Molecular Structure and Physiological Functions of GABA_B Receptors - Physiol. Review, 2004.
• Emerging structural explanations of ionotropic glutamate receptor function - FASEB J., 2004.
• N-Methyl-D-aspartate Receptors: Subunit Assembly and Trafficking to the Synapse - J. Biol. Chem., 2004.
• Structure and Function of the Glycine Receptor and Related Nicotinicoid Receptors - J. Biol. Chem., 2004.
• Glycine and N-Methyl-D-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications - Pharmacological Reviews, 1998.

Other Channels

• Calcium/Calmodulin Modulation of Olfactory and Rod Cyclic Nucleotide-gated Ion Channels - J. Biol. Chem., 2003.
• TRPV4 calcium entry channel: a paradigm for gating diversity - Am. J. Physiol., 2003.
• TRP Channel Proteins and Signal Transduction - Physiol. Review, 2002.
• Cyclic Nucleotide-Gated Ion Channels - Physiol. Review, 2002.
• Voltage-Gated Proton Channels and Other Proton Transfer Pathways - Physiol. Review, 2002.

Sites of Interest:

Ion Channels, Transmitters, Receptors, and Disease

The Ligand-gated Ion Channel Database