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Numerous drugs are enzyme inhibitors which may be divided into two types: competitive inhibitors and non-competitive inhibitors. The competitive inhibitor directly occupy the active site before the substrate can bind to it. The non-competitive inhibitor does not occupy the active site, but its binding to other region somehow inhibits the catalytic activity. HIV protease inhibitor is a competitive inhibitor, as shown below.
Review Articles: The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins - J. Biol. Chem., 2001.
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