MoBio Enzymes Chapter 2

Enzymes are the catalysts of biochemical reactions in the cell. Numerous drugs are enzyme inhibitors.

Prominent enzymes as drug targets:

  • HIV protease - essential for HIV replication. Its inhibitor has been able to control AIDS.
  • Angiotensin converting enzyme (ACE) - promotes contraction of blood vessels. Its inhibitors have been widely used to treat high blood pressure and congestive heart failure.
  • HMG-CoA reductase - essential for the synthesis of cholesterol. Its inhibitors (such as statins) can reduce the cholesterol level.
  • cGMP phosphodiesterase - catalyzes the conversion of cGMP into GMP. It is the target of the well known drug for treating impotence, Viagra.
  • Calcineurin - a phosphatase that plays an important role in immune responses. It is the target of the immunosuppressive drugs FK506 and cyclosporin A.