The motif is a characteristic domain structure consisting of two or more a
helices or b strands. Common examples
include coiled coil, helix-loop-helix,
zinc finger, leucine zipper, etc.
Many proteins also contain specific domains such as the SH2
domain.
Sites of Interest:
Protein domains - From Cell Signaling Technology.
Motif (a
search tool) - From Kyoto University, Japan.
Review Articles:
The ACT Domain: A Small Molecule Binding Domain and Its Role as a Common Regulatory Element - J. Biol. Chem., 2006.
Protein
families and RNA recognition - FEBS J., 2005.
The
RNA recognition motif, a plastic RNA-binding platform to regulate
post-transcriptional gene expression - FEBS J., 2005.
The
double-stranded RNA-binding motif, a versatile macromolecular docking platform - FEBS J., 2005.
PDZ
proteins retain and regulate membrane transporters in polarized epithelial
cell membranes - Am. J. Physiol., 2005.
Neuronal
PDZ Domains: A Promising New Molecular Target for Inhaled Anesthetics?
- Molecular Interventions, 2004.
The role
of nuclear Y-box binding protein 1 as a global marker in drug resistance
- Mol. Cancer Ther., 2004.
U2AF
homology motifs: protein recognition in the RRM world - Genes and Devel.,
2004.
Properties
and Functions of GAF Domains in Cyclic Nucleotide Phosphodiesterases and Other
Proteins - Mol. Pharm., 2004.
Structural and
Evolutionary Relationships among Protein Tyrosine Phosphatase Domains -
Molecular and Cellular Biology, 2001.
PDZ Domains:
Structural Modules for Protein Complex Assembly - J. Biol. Chem., 2001.
PDZ Protein
Interactions Regulating Glutamate Receptor Function and Plasticity - J.
Cell Biology, 2001.
All in the Family:
the BTB/POZ, KRAB, and SCAN Domains - Molecular and Cellular Biology,
2001.
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