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Blood Group Antigens

 


The antigens which determine blood types belong to glycoproteins and glycolipids.  There are three types of blood-group antigens: O, A, and B.  They differ only slightly in the composition of carbohydrates.

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Figure 1-B-5.  Blood-group antigens.  All humans contain enzymes which catalyze the synthesis of the O antigen.  Humans with A-type blood also contain an additional enzyme (called A-type enzyme here) which adds N-Acetylgalactosamine to the O antigen.  Humans with B-type blood contain another enzyme (called B-type enzyme here) which adds Galactose to the O antigen.  Humans with AB-type blood contain both A-type and B-type enzymes while humans with O-type blood lack both types of enzymes.