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|
Table 10-D-1. Cancer-associated genes.
| |
Gene |
Function |
| Proto-Oncogene |
VEGFC |
Growth factor |
| |
EGFR
(ErbB) |
Receptor tyrosine kinase |
| |
RET |
Receptor tyrosine kinase |
| |
IGF1R |
Receptor tyrosine kinase |
| |
Met |
Receptor tyrosine kinase |
| |
Src |
Non-receptor tyrosine kinase |
| |
Abl |
Non-receptor tyrosine kinase |
| |
Ras, H-,
K-,
N- |
Signal transduction |
| |
myc |
Transcription factor |
| |
myb |
Transcription factor |
| |
bcl-2 |
Apoptosis inhibition |
| |
Mdm2 |
Downregulation of p53 |
| |
NCAD
(CDH2) |
Promotes cell mobility |
| |
CTNNB1 |
Cell adhesion |
| Tumor Suppressor |
p53
(TP53) |
Transcription factor |
| |
Rb1 |
Cell cycle brake |
| |
p16
(CDKN2A) |
Cdk4 inhibition |
| |
PTEN |
Phosphatase |
| |
STK11
(LKB1) |
Serine/threonine protein kinase |
| |
NF-1 |
Ras inhibition |
| |
BRCA1 |
Transcription regulator |
| |
DPC4
(MADH4) |
Transcription factor |
| |
WT1 |
Transcription factor |
| |
MEN-1 |
Transcription co-repressor |
| |
PTCH |
Transcription co-repressor |
| |
ECAD
(CDH1) |
Cell adhesion |
| |
CTNNA1 |
Cell adhesion |
| |
APC |
Cell adhesion |
| |
TSC1 |
Vesicular transport |
| DNA Repair |
ATM |
Protein kinase |
| |
MSH2 |
Mismatch Repair |
| |
MSH6 |
Mismatch Repair |
| |
MLH1 |
Mismatch Repair |
| Virus |
Viral Gene |
Possible mechanism |
| EBV |
LMP-1 |
Activate B cells like CD40 |
| HBV |
X |
Inactivate p53 |
| HPV 16, 18 |
E6 |
Downregulate p53 |
| |
E7 |
Inactivate pRB |
| HTLV-1 |
tax |
Activate IL genes |
| HIV-1 |
tat |
Stimulate Kaposi tumor growth |
Oncogenes are the genes that stimulate excessive cell proliferation. The normal genes that may be mutated to
become oncogenes
are called proto-oncogenes. Tumor suppressor genes may inhibit cell division.
Review Articles:
- ABL
Oncogenes and Phosphoinositide 3-Kinase: Mechanism of Activation and
Downstream Effectors - Cancer Research, 2005.
- Membrane
organization and tumorigenesis: the NF2 tumor suppressor, Merlin - Genes and Development,
2005.
- Targeting
ErbB receptor signaling: A pan-ErbB approach to cancer - Mol. Cancer
Thera., 2004.
- A
strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling
pathway - Mol. Cancer Thera., 2004.
- Altered
Hsp90 function in cancer: A unique therapeutic opportunity - Mol.
Cancer Thera., 2004.
- Sigma
Receptors and Cancer - Cancer Research, 2004.
- PTEN
function: how normal cells control it and tumour cells lose it -
Biochem. J., 2004.
- Reconstructing
MYC - Genes and Development, 2003.
- Differential
Regulation of EphA2 in Normal and Malignant Cells - Am. J. Pathology,
2003.
- Transcriptional
regulation of the telomerase hTERT gene as a target for cellular
and viral oncogenic mechanisms - Carcinogenesis, 2003.
- PTEN:
tumour suppressor, multifunctional growth regulator and more - Hum.
Mol. Genet., 2003.
- Protean
PTEN: Form and Function - Am. J. Hum. Genet., 2002.
- Genetics
and new approaches to cancer therapy - Carcinogenesis, 2002.
- Insulin-like
Growth Factor-binding Protein 2 in Tumorigenesis - Cancer Research,
2001.
- Dysregulation
of Met receptor tyrosine kinase activity in invasive tumors - J.
Clinical Investigation, 2002.
- c-Myc
Target Genes Involved in Cell Growth, Apoptosis, and Metabolism - Molecular and Cellular Biology,
1999.
- Wnt
signaling and cancer - Genes and Development, 2000.
- The INK4a/ARF
locus in murine tumorigenesis - Carcinogenesis, 2000.
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