Prostate Cancer

Prostate cancer often begins with the loss of NKX3.1 gene, resulting in the  morphological change from normal epithelium to prostatic intraepithelial neoplasia (PIN). Further loss of PTEN and Rb genes converts the PIN lesion into invasive carcinoma. The final metastasis is accelerated by the loss of p53 (illustration from Genes and Development).

Prominent Genes in Prostate Cancer

NKX3A(NKX3.1), PTEN, RB1, p53, p27, p21, PCA3, KAI1.

Review Articles

Mass Spectrometry-based Expression Profiling of Clinical Prostate Cancer - Mol. Cell. Proteomics, 2005.

Bortezomib as a Potential Treatment for Prostate Cancer - Cancer Research, 2004.

Detection of Prostate Cancer and Predicting Progression - Clinical Cancer Research, 2004.

The complex genetic epidemiology of prostate cancer - Human Molecular Genetics, 2004.

Protean PTEN: Form and Function - Am. J. Hum. Genet., 2002.

The Control of Prostate-Specific Antigen Expression and Gene Regulation by Pharmacological Agents - Pharmacological Reviews, 2001.

Genetics of Prostate Cancer: Too Many Loci, Too Few Genes - Am. J. Hum. Genet., 2000.

Molecular genetics of prostate cancer - Genes and Development, 2000.