HomeAlzheimer's Disease


Author: Frank Lee

Book ID: 3R3456
Released: 2015-11-26

Format: BSON
File Size: 0.7 MB

Read Online



Alzheimer's disease and other neurodegenerative disorders may arise from a common pathogenic cascade: BDNF deficiency > miR-132 down-regulation > Tau level up > Hyperexcitability > Calcium overload. Over-production of Tau proteins has been demonstrated to cause hyperexcitability (see The Role of Microtubules in Epilepsy). The activation of mTOR promotes Tau production. Therefore, mTOR activation enhances excitability. This novel mechanism is now well-documented (see Epilepsy and mTOR). The model agrees with the hyperfunction theory of aging and explains why mTOR plays a crucial role in aging.


Also of Interest

Image AIDS
Image Understanding Nanodevices
National Cancer Institute
Image Biology I
OpenStax College
Image Understanding Cancer Genomics
National Cancer Institute
Image Understanding Molecular Diagnostics
National Cancer Institute
Image Anatomy and Physiology I
OpenStax College
Image Understanding Genetic Variation (SNPs)
National Cancer Institute