Author: Frank Lee
Book ID: 3R3456
File Size: 0.7 MB
Alzheimer's disease and other neurodegenerative disorders may arise from a common pathogenic cascade:
BDNF deficiency > miR-132 down-regulation > Tau level up > Hyperexcitability > Calcium overload. Over-production of Tau proteins has been demonstrated to cause hyperexcitability (see The Role of Microtubules in Epilepsy).
The activation of mTOR promotes Tau production.
Therefore, mTOR activation enhances excitability.
This novel mechanism is now well-documented (see Epilepsy and mTOR).
The model agrees with the hyperfunction theory of aging and explains why mTOR plays a crucial role in aging.
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